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JabsAndTabs

Weight loss injections · semaglutide

Wegovy (semaglutide): UK guide

A once-weekly semaglutide injection licensed in the UK for weight management and, in some patients, to reduce cardiovascular risk.

Wegovy at a glance

Licensed in the UK for weight managementPrescription-only medicine
Active ingredient
semaglutide
Drug class
GLP-1 receptor agonist
Manufacturer
Novo Nordisk
How it is taken
Injection, once a week
Device
FlexTouch pen
Dose range
0.25mg to 7.2mg
MHRA authorisation
MHRA authorised for weight management, September 2021
NICE guidance
NICE TA875 (March 2023)

Regulatory source: gov.uk

Licensed in the UK for weight management. MHRA authorised for weight management, September 2021.

The main clinical evidence for Wegovy in weight management comes from the STEP trial programme. Read what the trials show for context on realistic expectations.

Wegovy doses

Treatment starts low and steps up gradually to help your body adjust.
Doses listed in the UK product information for Wegovy. Your prescriber decides your dose; not everyone increases to the highest dose.
DoseRoleEarliest start (if increased at every step)
Wegovy 0.25mgStarting doseWeek 1
Wegovy 0.5mgStep-up doseWeek 5
Wegovy 1mgStep-up doseWeek 9
Wegovy 1.7mgStep-up doseWeek 13
Wegovy 2.4mgMaintenance doseWeek 17
Wegovy 7.2mgMaximum doseAuthorised by the MHRA in January 2026 for adults with obesity (BMI of 30 or more) only. Not covered by NICE TA875.Week 21
  1. Step 10.25mgfrom week 1
  2. Step 20.5mgfrom week 5
  3. Step 31mgfrom week 9
  4. Step 41.7mgfrom week 13
  5. Step 52.4mgfrom week 17
  6. Step 67.2mgfrom week 21

The UK product information says to stay on each dose for at least 4 weeks before increasing. Weeks shown are the earliest possible; many people stay on a dose for longer, and some stay on a lower dose.

Wegovy side effects

Select a side effect for self-care tips and guidance on when to seek help.

When to get urgent help

Stop taking the medicine and get urgent medical help (NHS 111, A&E or 999) if you have severe, persistent stomach pain that may spread to your back, signs of a serious allergic reaction, or yellowing of your skin or eyes. Report suspected side effects to the MHRA Yellow Card scheme.

Everything about Wegovy

How Wegovy compares

UK providers listing Wegovy

Listed alphabetically. Provider details are being verified; we never rank by commission.

Wegovy: frequently asked questions