Mounjaro vs Wegovy tablets (oral semaglutide): how they compare
Mounjaro (tirzepatide) and Wegovy tablets (oral semaglutide) compared side by side: how they work, dosing, side effects and UK status.
Key differences
- Mounjaro is a GIP/GLP-1 receptor agonist, while Wegovy tablets (oral semaglutide) is a GLP-1 receptor agonist.
- Mounjaro is an injection; Wegovy tablets (oral semaglutide) is a tablet.
- Mounjaro is taken once a week, whereas Wegovy tablets (oral semaglutide) is taken once a day.
Side-by-side
| Attribute | Mounjaro | Wegovy tablets (oral semaglutide) |
|---|---|---|
| Active ingredient | tirzepatide | semaglutide (oral) |
| Drug class | GIP/GLP-1 receptor agonist | GLP-1 receptor agonist |
| Manufacturer | Eli Lilly | Novo Nordisk |
| Form | Injection | Tablet |
| How often | once a week | once a day |
| Device | KwikPen (multi-dose pre-filled pen) | None (tablet) |
| Starting dose | 2.5mg | 1.5mg |
| Dose range | 2.5mg to 15mg | 1.5mg to 25mg |
| UK status | Licensed in the UK for weight management | Licensed in the UK for weight management |
| NICE guidance | NICE TA1026 (December 2024) | Not yet verified |
| Common side effects | Nausea, Diarrhoea, Constipation, Vomiting, Indigestion and reflux, Injection site reactions | Nausea, Diarrhoea, Constipation, Vomiting, Indigestion and reflux |
Frequently asked questions
Comparison guides
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- Wegovy Injections vs Oral GLP-1 Tablets
- SURMOUNT-5: The Head-to-Head Trial of Tirzepatide vs Semaglutide
- Saxenda (Liraglutide) vs Newer GLP-1 Medications