Is constipation a common side effect of Mounjaro?

Constipation is among the side effects most often reported with Mounjaro. It tends to be most noticeable when starting treatment or after a dose increase, and often improves with time. The Patient Information Leaflet gives the official frequency.

Should I stop Mounjaro because of constipation?

Do not stop or change your treatment without speaking to your prescriber, unless you have symptoms that need urgent care, such as severe persistent stomach pain. Your prescriber may suggest staying on your current dose for longer, adjusting your dose or other measures. You can also report suspected side effects to the MHRA Yellow Card scheme.

Mounjaro and constipation: causes, tips and when to get help

Constipation on Mounjaro (tirzepatide): why it happens, self-care measures and the warning signs that need medical help.

Get urgent medical help if:

you have severe stomach pain, a swollen tummy and are vomiting, or cannot pass wind (possible bowel obstruction)

Call 999 or go to A&E in an emergency. For urgent advice, call NHS 111.

About constipation on Mounjaro

Slower movement of food through the gut and eating less can both make constipation more likely during GLP-1 treatment.

Constipation is listed among the commonly reported side effects of Mounjaro in our reference data.

Things that may help

Drink plenty of fluids through the day
Include fibre from vegetables, fruit, pulses and wholegrains where you can
Stay as physically active as you are able
Ask a pharmacist before using a laxative

A pharmacist can advise on suitable over-the-counter options.

Speak to your prescriber if

you have not opened your bowels for several days despite self-care
constipation is painful or keeps coming back

Report suspected side effects through the MHRA Yellow Card scheme. Reports help the MHRA monitor the safety of medicines.

Frequently asked questions

Related guides

Other Mounjaro side effects

All Mounjaro side effects